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The Highlands region supported Bonnie Prince Charlie during the Jacobite uprising of 1745. This area was primarily made up of Scottish clans who had strong loyalty to their own clan leaders and to the Stewart dynasty, of which Bonnie Prince Charlie was a representative. The climate in the Highlands was conducive to the support of the rebellion, and many clans rallied behind Charlie due to a mix of nationalistic feelings, historical grievances against English rule, and the desire to restore the Stuart monarchy to the throne of Great Britain.

The other regions, like the Lowlands, were less supportive of the Jacobite cause, often because of differing economic interests, political beliefs, and a stronger allegiance to the established Hanoverian government. The Islands and Western Isles also had distinct loyalties, influenced by their geographical and socio-economic contexts, which did not necessarily align with the main supporters of Bonnie Prince Charlie in the Highlands.